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What is Provera?

Provera (medroxyprogesterone) is similar to the progesterone that your body makes naturally and is given when your body is not making enough of it. This medication is used to treat absent or irregular menstrual periods, abnormal uterine bleeding, to decrease the risk of endometrial hyperplasia and to prevent overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy.

Always read the patient information and instructions carefully before using this medication.

• Provera should be taken orally. The schedule to take this medication will depend on why you are taking it. Always follow your doctor’s directions.
• Your Provera dosage is based on your medical condition and your response to treatment. Do not change your dosage or the frequency you take this medication unless advised by a doctor.
• Tell your doctor if your condition does not improve or worsens.

Make sure to tell your doctor and pharmacist:

• If you have any drug allergies or if you allergic to peanuts or soy.
• Which other prescription and non-prescription medications you currently take.
• Your medical history especially of blood clots, bleeding in the brain, liver disease, cancer of the breast or other female organs, vaginal bleeding of an unknown cause, loss of pregnancy, stroke, heart attack, kidney disease, obesity, heart disease, high blood pressure, seizures, migraines, asthma, depression, high cholesterol levels or diabetes.
• Your personal and family history of breast lumps or cancer.
• If you are using marijuana.
• If you will be having surgery or will be confined to a bed or chair for a long period of time such as on a long flight. These conditions may increase the risk of blood clots and you may need to temporarily stop taking Provera or take special precautions.
• If you are breast feeding as Provera passes into breast milk.

Also be aware that:

• This medication may make you dizzy or drowsy. Do not drive, use machinery or do anything else requiring alertness until it can be done safely.
• You should limit your alcohol intake while taking this medication. Ask your doctor what a safe amount of alcohol for you is.
• You should not smoke while taking Provera. Smoking combined with estrogen further increases your risk for strokes, blood clots, heart attacks and high blood pressure.
• Provera can cause dark or blotchy areas on your skin and face which may be worsened by sunlight. You should limit your time in the sun and wear protective clothing and use sunscreen. Avoid tanning booths and sunlamps.
• You must not use medroxyprogesterone while pregnancy as it may harm an unborn baby, especially during the first four months of pregnancy.

Common Provera side effects may include but are not limited to:

• Changes in your menstrual periods, spotting or breakthrough bleeding.
• Vaginal discharge or itching.
• Breast discharge or tenderness.
• Headaches.
• Dizziness, depression or nervousness.
• Bruising or swelling of the veins.
• Sleep problems.
• Vision changes or difficulty wearing contact lenses.
• Premenstrual type symptoms such as bloating, mood changes or fluid retention.
• Itching, rash, acne, loss of scalp hair or hair growth.
• Nausea, bloating, weight gain or stomach discomfort.

Contact your doctor if you experience any of the following side effects of Provera:

• Vaginal bleeding if you have already gone through menopause.
• Lightheadedness or the feeling that you might pass out.
• Breast lumps.
• Jaundice.
• Signs of a heart attack such as nausea, sweating, chest pain, chest pressure or a pain spreading to your jaw or shoulder.
• Signs of a stroke such as sudden, severe headache, slurred speech, problems with balance or vision or a sudden numbness or weakness especially on one side of your body.
• Swelling in the hands, ankles or feet.
• Signs of depression such as sleep problems, headache, mood changes or dizziness.
• Fever.
• Signs of a blood clot in the lung such as chest pain, sudden coughing, wheezing, rapid breathing or coughing up blood.
• Signs of a blood clot in your leg such as pain, swelling, warmth, or redness in one or both legs.
• Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.

Q: What should I avoid while taking Provera?

A: You should avoid smoking while taking Provera as it can greatly increase the risk of blood clots.

Q: What should I do if I miss a dose of Provera?

A: If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, then skip your missed dose